《速度与激情4》延用了《速度与激情：东京漂移》的华裔导演林诣彬，演员方面却是原班人马出阵，人物与剧情都完美承袭《速度与激情2》。
| 角色 | 演员 | 备注 |
|---|---|---|
| Dominic Toretto | 范·迪塞尔Vin Diesel | |
| Brian O'Conner | 保罗·沃克Paul Walker | 已故 |
| Mia Toretto | 乔丹娜·布鲁斯特Jordana Brewster | |
| Letty | 米歇尔·罗德里格兹Michelle Rodriguez | |
| Campos | 约翰·奥提兹John Ortiz | |
| Fenix Rise | 拉兹·阿隆索Laz Alonso | |
| Gisele Harabo | 盖尔·加朵Gal Gadot | |
| Penning | Jack Conley | |
| Agent Ben Stasiak | 希亚·温汉Shea Whigham | |
| Agent Sophie Trinh | 丽萨·拉皮拉Liza Lapira | |
| Han Lue | 成康 | |
| Himself | Don Omar | |
| Cara | Mirtha Michelle | |
| Dwight | Greg Cipes | |
| Tego | Tego Calderon | |
| David Park | Ron Yuan | |
| Gas Truck Driver | Alejandro Patino | |
| Virgil | Joe Hursley | |
| Juvenal | César García Gómez | |
| BMW Driver | 布兰登·T·杰克逊/Brandon T. Jackson | |
| Silvia Driver | Mousa Kraish | |
| Malik | Neil Brown Jr. | |
| Tash | 威尔莫·卡德隆Wilmer Calderon | |
| Drug Runner#3 | 约瑟夫·朱利安·索里亚Joseph Julian Soria | |
| Drug Runner#4 (as Don Tai Theerathada) | Don Theerathada | |
| Braga Double | Robert Miano | |
| Scar Thug | Luis Moncada | |
| Thug | Kofi Natei | |
| Federal Investigator | McCaleb Burnett | |
| Lead Investigator | Greg Collins | |
| FBI Agent#1 | Monique Curnen | |
| FBI Agent#2 | Jimmy Lin | |
| FBI Agent#3 | Roger Fan | |
| FBI Agent#4 | Danny LaCava | |
| FBI Agent#5 | Lou Reyes | |
| FBI Assistant | Breon Ansley | |
| Border Agent#1 | Assaf Cohen | |
| Border Agent#2 | Loren Lazerine | |
| Judge | Lou Beatty Jr. | |
| Bailiff | Julian Starks | |
| Impound Clerk | Christopher Gehrman | |
| Mexican Priest | Marco Rodriguez | |
| Hot Girl#1 | Naureen Zaim | |
| Hot Girl#2 | Rebecca O'Donahue | |
| Hot Girl#3 | Sharon Zeev | |
| Woman in Hallway | Alexandra Castro | |
| Girl at the Beach | Jaimie Sullivan | |
| GPS Voice | Leigh Folsom | |
| FBI Agent(uncredited) | Rio Ahn | |
| Chico(uncredited) | Barnaby Barrilla | |
| Bar girl1 (uncredited) | Hazel Calderon | |
| Club goer(uncredited) | Jason Castle | |
| Braga's Henchman (uncredited) | Abraham Chaidez；Rodney Sciba | |
| Fenix's Henchman #2 (uncredited) | Daniel Colletti | |
| Campos Henchman(uncredited) | Jason L. Davis | |
| Dwight's Girl (uncredited) | Kristen De Luca | |
| Club girl(uncredited) | 梅乐迪丝·吉安格兰Meredith Giangrande | |
| Henchman(uncredited) | Guillermo Gomez | |
| Fenix's Henchman (uncredited) | Chicago Jones | |
| Henchmen(uncredited) | Fatal Instinct | |
| Santa Domingo Girl(uncredited) | Jessica Martinez | |
| Girl Kissing in Hallway(uncredited) | Mycole Metcalf | |
| Drug Runner#5 (uncredited) | Frank Miranda | |
| Cartel Driver#1 (uncredited) | Michael Nance | |
| Dancer(uncredited) | Christina Neferis；Victoria Parsons | |
| Model | Victoria Parsons | |
| Prisoner on Bus(uncredited) | Hash Patel | |
| Drug runner's #2 girl (uncredited) | Bruna Rubio | |
| Dancer#2 (uncredited) | Sagine | |
| Dwight's girl (uncredited) | Holly Weber | |
| Prisoner on bus(uncredited) | Dennis Winters | |
| Braga's Henchman #1 (uncredited) | David Zahedian |